It's been a while since I've done one of these. Let's give it a shot. I've already covered the movie sets elsewhere, and the Mixels should be obvious. Let's take a moment to look at some of the other new sets.
42020 Twin-Rotor Helicopter. 145 parts for $12.99. As most people can figure out, I'm a big fan of Technic parts.
10667 Juniors Construction. 160 parts for $14.99. Plenty of fiddly bits and plenty of color. The only minuses are the mono-body vehicle piece and the minifig.
70161 Tremor Track Infiltration. 241 parts for $19.99. I've always liked the Agents line. This set is a tad monochromatic, but Tan and Dark tan can be interesting colors to work with.
70141 Vardy's Ice Vulture Glider. 217 parts for $19.99. This set is similar in color to the one above. It does have Translucent Light Blue pieces to make things interesting though.
60056 Tow Truck. 227 parts for $19.99. I feel like I get to recommend City sets so rarely lately, it's almost worth a celebration every time I do. This set has plenty of parts in Blue, White, Red, and Light Bley.
70130 Sparratus’ Spider Stalker. 292 parts for $24.99. Lots of Technic bits in this one along with useful system pieces.
10673 Race Car Rally. 350 parts for $29.99. Plenty of basic bricks for terrain and a healthy amount of the fiddly stuff we love.
21020 Trevi Fountain. 731 parts for $49.99. $0.07 per piece, and while most of the set is standard bricks there are plenty of clip plates, bar plates, jumpers, skeleton arms, and SNOT bricks to make this worth it.